Translational Control in Myeloid Disease

Over the years a wealth of information on the role played by transcription factors in myeloid biology has contributed to our understanding of both normal and abnormal myeloid development. However, the regulation of mRNA translation in myeloid cell maturation has, in comparison, been a neglected area of study. A better understanding of the translational control of myeloid gene expression will undoubtedly provide important insights into both normal and abnormal myeloid maturation. This chapter summarizes our current understanding of the regulation of myeloid gene expression at the mRNA translational level and delineates levels of disruption in myeloid disease, with an emphasis on leukemias.